Intraperitoneal noxythiolin and povidone - iodine in experimental peritonitis
نویسندگان
چکیده
The efficacy of intraperitoneal noxythiolin and povidone-iodine was compared in mice and rats with induced Gram-negative peritonitis. Noxythiolin 1%y solution reduced the mortality of mice from 65 to 41%y (P<01) but was ineffective in rats. Povidone-iodine (6-0-7-5 mg available iodine/kg body weight) significantly reduced the mortality of both mice (P<0001) and rats (P<0.01) in treated animals compared to matched controls. The mortality rate of rats treated with povidone-iodine was significantly less than those treated with noxythiolin (P<001).
منابع مشابه
Effect of noxythiolin on experimental peritonitis 0 . J . A . GILMORE
The intraperitoneal instillation of noxythiolin in the treatment of peritonitis is widespread in clinical practice despite contradictory evidence as to its efficacy. In this light the value of noxythiolin was reappraised by studying its effect in guinea-pigs and mice with induced bacterial peritonitis. Treatment with a 1% solution of noxythiolin reduced the mortality rate of mice by 14% (P<0-1)...
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The intraperitoneal instillation of noxythiolin in the treatment of peritonitis is widespread in clinical practice despite contradictory evidence as to its efficacy. In this light the value of noxythiolin was reappraised by studying its effect in guinea-pigs and mice with induced bacterial peritonitis. Treatment with a 1% solution of noxythiolin reduced the mortality rate of mice by 14% (P less...
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